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Robert B. Goldberg




Email Address:
bobg@ucla.edu
Work Address:
Laboratory
LSB
Los Angeles, CA 90095
UNITED STATES

Office
Department of Molecular, Cell and Developmental Biology
LSB 2832
Box 951606
Los Angeles, CA 90095
UNITED STATES

Fax Number:
(310) 206-3987
Work Phone Number:
(310) 825-3270
(310) 825-9093

Web Address:
http://www.mcdb.ucla.edu/Research/Goldberg

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Professor
Biology
Member
Molecular, Cell, and Developmental Biology, Cell & Developmental Biology GPB Home Area, Gene Regulation GPB Home Area, Genetics & Genomics GPB Home Area
Bio:

Bob Goldberg is a plant molecular biologist who specializes in the area of plant genomics. The goal of his research has been to understand how plant cells differentiate and how genes are activated selectively in specialized cell types during plant development. Professor Goldberg's research has provided a conceptual foundation for the processes that regulate gene expression in higher plants. In collaboration with others, he utilized genes identified in his laboratory to develop a novel system to genetically engineer for male fertility control in crop plants. This system was used to develop new hybrid varieties of canola plants that have significantly increased yields of oil. His current research is using state-of-the-art genomics technologies to identify all of the genes required to “make a seed.” Professor Goldberg received a B.S. in Botany at Ohio University, and M.S. and Ph.D. degrees in Plant Genetics from The University of Arizona. Professor Goldberg was a Postdoctoral Fellow at the California Institute of Technology and joined the UCLA faculty in 1976. Professor Goldberg served twice as Director of the Plant Genetics Program at the USDA, has been on the Editorial Boards of many internationally recognized journals such as Science, and was the Founding Editor and Editor-In-Chief of The Plant Cell, the leading journal in the area of plant molecular biology. He has been the organizer of many major international plant molecular biology meetings, is the Director of The Seed Institute –- an intercampus “institute without walls” within the University of California dedicated to unraveling the processes that control seed development. Professor Goldberg has given hundreds of lectures on his research world-wide, and has received several awards recognizing his contributions to the field of plant molecular biology. These include election to the National Academy of Sciences, the National Order for Scientific Merit from the President of Brazil, being named as a UCLA Faculty Research Lecturer, and being listed as making one of the "top 15" Discoveries in UCLA's 75-year history. Professor Goldberg is highly committed to undergraduate and graduate education and is an "expert" in making science "come alive." Professor Goldberg has received Distinguished Teaching Awards from the Department of Biology and the Department of Molecular, Cell, and Developmental Biology, and was awarded the Luckmann Distinguished Teaching Award from the Academic Senate. He has also been awarded the Gold Shield Prize for Excellence in Research and Undergraduate Education by the Academic Senate and was named as one of the "top 20" Professors in UCLA's 75-year history. Recently, Professor Goldberg was awarded a Howard Hughes Medical Institute University Professorship with the goal of expanding undergraduate opportunities in discovery-oriented research.

Publications:
Le, B.H., Cheng, C., Bui, A.Q., Wameister, J.A., Henry, K.F., Pelletier, J., Kwong, L., Belmonte, M., Kirkbride, R., Horvath, S., Drews, G.N., Fischer, R.L., Okamuro, J.K., Harada, J.J., and Goldberg, R.B. Global analysis of gene activity during Arabidopsis seed development and identification of seed-specific transcription factors. Proc. Natl. Acad. Sci. USA. doi: 10.1073/pnas.1003530107. 2010; .
Kawashima, T. and Goldberg, R.B. The suspensor: not just suspending the embryo. Trends in Plant Science. doi:10.1016/j.tplants.2009.11.002. 2010; 1360-1385.
Kawashima, T., Wang, X., Henry, K.F., Bi, T., Weterings, K., and Goldberg, R.B. Identification of cis-regulatory sequences that activate transcription in the suspensor of plant embryos. Proc. Natl. Acad. Sci. USA. doi: 10.1073/pnas.0813276106. 2009; 106: 3627-3632.
Stone, S.L., Braybrook, S.A., Paula, S. Al., Kwong, L.W., Pelletier, J., Hsieh, T.F., Fischer, R.L., Goldberg, R.B., and Harada, J.J. Arabidopsis LEAFY COTYLEDON2 induces maturation traits and auxin activity: implications for somatic embryogenesis. Proc. Natl. Acad. Sci. USA. doi: 10.1073/pnas.0712364105. 2008; 105: 3151-3156.
Le, B.H., Wagmaister, J.A., Kawashima, T., Bui, A.Q., Harada, J.J., and Goldberg, R.B. Using genomics to study legume development. Plany Physiology. doi: 10.1104/pp.107.10036. 2007; (144): 562-584.
Gehring, M., Huh, J.-H., Hisieh, T-F, Penterman, J., Choi, Y., Harada, J.J., Goldberg, R.B., and Fischer, R.L. DEMETER DNA glycolosylase establishes MEDEA polycomb self-imprinting by allele-specific demethylation. Cell 2006; 124(Cover Article): 495-506.
Xiao, W., Custard, K.D., Brown, R.C., Lemmon, B.E., Harada, J.J., Goldberg, R.B., and Fischer, R.L. DNA methylation is critical for Arabidopsis embryogenesis and seed viability. Plant Cell 2006; 18: 805-814.
Braybrook, S.A., Stone, S.L., Park, S., Bui, A.Q., Le, B.L., Fischer, R.L., Goldberg, R.B., and Harada, J.J. Genes directly regulated by LEAFY COTYLEDON2 provide insight into control of embryo maturation and somatic embryogenesis. Proc. Natl. Acad. Sci. USA 2006; 103, 3468-3473.
Xiao, W., Brown, R.C., Lemmon, B.E., Harada, J.J., Goldberg, R.B., andd Fischer, R.L. Regulation of seed size by hypothylation of maternal and paternal genomes. Plant Physiology 2006; 142,1160-1168.
Ohto, M-a., Fischer, R.L., Goldberg, R.B., Nakamura, K., and Harada, J.J. Control of seed mass by APETELA2. Proc. Natl. Acad. Sci. USA 2005; 102, 3123-3128.
Sanders, P.M., Bui, A. Q., Le, B.H., and Goldberg, R.B. Differentiation and degeneration of cells that play a major role in tobacco anther dehiscene. Sex. Plant. Reprod 2005; 17, 219-241.
Hamilton, R., Flavell, R.B., and Goldberg, R.B. Plant Biotechnology: Advances in Energy, and Health. eJOURNALUSA. Economic Perspectives. U.S. Department of State. 2005; 10, 17-20.
Yamagishi, K., Nagata, N., Yee, K.M., Braybrook, S.A., Pelletier, J., Fujioka, S., Yoshida, S., Fischer, R.L., Goldberg, R.B., and Harada, J.J. TANMEI/EMB2757 encodes a WD repeat protein required for embryo and vegetative development in Arabidopsis. Plant Physiology 2005; 139, 163-73.
Sanders, P. M., Bui, A. Q., Le, B. H., and Goldberg, R. B. Differentiation and degeneration of cells that play a major role in tobacco anther dehiscence. Sexual Plant Reproduction. 2004; In Press: 1-24.
Goldberg, R.B. Plant Reproduction - Ten Years Later. Plant Cell 2004; (Supplement): s1-s2.
Lee, H., Fischer, R. L., Goldberg, R. B., and Harada, J. J. Arabidopsis LEAFY COTYLEDON1 represents a subunit of the CAAT-binding transcription factor. Proc. Natl. Acad. Sci. USA 2003; 100: 2152-2156.
Apuya, N. R., Yadegari, R., Fischer, R. L., Harada, J. J., Zimmerman, J. L., and Goldberg, R. B. The Arabidopsis Embryo Mutant schlepperless has a defect in the Chaperonin-60a gene. Plant Physiol 2001; 126: 717-730.
Sanders, P. M., Beals, T. P., Weterings, K., McIntire, K. N., Bui, A. Q., Hsu, Y-C., Lee, P. Y., Truong, M. T., Anther developmental defects in Arabidopsis thaliana male-sterile mutants. Sex. Plant. Reprod 1999; 11: 1-27.
Lotan, T., Ohto, M., Yee, K.M., West, M.A.L., Lo, R., Kwong, R.W., Yamagishi, K., Fischer, R.L., Goldberg, R.B., and Harada, J.J. Arabidopsis LEAFY COTYLEDON1 is a key regulator of embryogenesis. Cell 1998; 93: 1195-1205.
Goldberg, R.B., de Paiva, G. and Yadegari, R. Plant embryogenesis: zygote to seed. Science 1994; 266: 605-614.
Goldberg, R.B. To Eat or Not to Eat. Los Angeles Daily News 2004; Editorial: .
Choi, Y Harada, JJ Goldberg, RB Fischer, RL An invariant aspartic acid in the DNA glycosylase domain of DEMETER is necessary for transcriptional activation of the imprinted MEDEA gene. Proceedings of the National Academy of Sciences of the United States of America. . 2004; 101(19): 7481-6.
Xiao, W Gehring, M Choi, Y Margossian, L Pu, H Harada, JJ Goldberg, RB Pennell, RI Fischer, RL Imprinting of the MEA Polycomb gene is controlled by antagonism between MET1 methyltransferase and DME glycosylase. Developmental cell. . 2003; 5(6): 891-901.
Kwong, RW Bui, AQ Lee, H Kwong, LW Fischer, RL Goldberg, RB Harada, JJ LEAFY COTYLEDON1-LIKE defines a class of regulators essential for embryo development. The Plant cell. . 2003; 15(1): 5-18.
Choi, Y Gehring, M Johnson, L Hannon, M Harada, JJ Goldberg, RB Jacobsen, SE Fischer, RL DEMETER, a DNA glycosylase domain protein, is required for endosperm gene imprinting and seed viability in arabidopsis. Cell. . 2002; 110(1): 33-42.
Apuya, NR Yadegari, R Fischer, RL Harada, JJ Goldberg, RB Harada, JH RASPBERRY3 gene encodes a novel protein important for embryo development. Plant physiology. . 2002; 129(2): 691-705.
Weterings, K Apuya, NR Bi, Y Fischer, RL Harada, JJ Goldberg, RB Regional localization of suspensor mRNAs during early embryo development. The Plant cell. . 2001; 13(11): 2409-25.
Stone, SL Kwong, LW Yee, KM Pelletier, J Lepiniec, L Fischer, RL Goldberg, RB Harada, JJ LEAFY COTYLEDON2 encodes a B3 domain transcription factor that induces embryo development. Proceedings of the National Academy of Sciences of the United States of America. . 2001; 98(20): 11806-11.
Goldberg, RB From cot curves to genomics. How gene cloning established new concepts in plant biology. Plant physiology. . 2001; 125(1): 4-8.
Sanders, PM Lee, PY Biesgen, C Boone, JD Beals, TP Weiler, EW Goldberg, RB The arabidopsis DELAYED DEHISCENCE1 gene encodes an enzyme in the jasmonic acid synthesis pathway. The Plant cell. . 2000; 12(7): 1041-61.
Beals, TP Goldberg, RB A novel cell ablation strategy blocks tobacco anther dehiscence. The Plant cell. . 1997; 9(9): 1527-45.
Smith Terry J, Tsai Chieh Chih, Shih Mei-Ju, Tsui Shanli, Chen Beiling, Han Rui, Naik Vibha, King Chris S, Press Chris, Kamat Shweta, Goldberg Robert A, Phipps Richard P, Douglas Raymond S, Gianoukakis Andrew G Unique attributes of orbital fibroblasts and global alterations in IGF-1 receptor signaling could explain thyroid-associated ophthalmopathy. Thyroid : official journal of the American Thyroid Association. 2008; 18(9): 983-8.
Belmonte, M.F., Kirkbride, R.C., Stone, S.L., Pelletier, J.M., Bui, A.Q., Yeung, E.C., Hashimoto, M., Fei, J., Harada, C.M., Munoz, M.D., Le, B.H., Drews, G.N., Brady, S.M., Goldberg, R.B., and Harada, J.J. Comprehensive developmental profiles of gene activity in regions and subregions of the Arabidopsis seed. Proc. Natl. Acad. Sci. USA 2013; .


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